Acknowledgments: This work was funded by grants from the Sao Paulo Research Foundation - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) and the Brazilian Scientific and Technological Development Council - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq). The authors thank the family who participated in this research. The authors would also like to express their appreciation to Dr. Lynda L. Harrison for her support.
